The use and function of zinc oxide in pig farms

2021-02-05

The advantages of zinc oxide include preventing diarrhea and promoting growth in weaned piglets. Recent research advances indicate that its mechanism of action is achieved through multiple regulatory pathways. Higher levels of zinc oxide are added to piglet feed to meet requirements, as zinc absorption decreases by about 30% after weaning, and bioavailability may be less than 20%. In addition, zinc oxide has been shown to promote growth by regulating the secretion of gut peptides that stimulate appetite.


　　 Zinc oxide The advantages of zinc oxide include preventing diarrhea and promoting growth in weaned piglets. Recent research advances indicate that its mechanism of action is achieved through multiple regulatory pathways. Adding higher levels of zinc oxide to piglet feed to meet requirements is necessary, as zinc absorption decreases by about 30% after weaning, and bioavailability may be less than 20%. In addition, zinc oxide has been shown to promote growth by regulating the secretion of brain-gut peptides that stimulate appetite.


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　　Zinc oxide improves intestinal barrier function by increasing the expression of intestinal insulin-like growth factor 1, reducing cell permeability in the expression of intestinal tight junction proteins.

　　Zinc oxide can reduce the release of pro-inflammatory histamine, inhibit intestinal mast cell activation and proliferation, thus having an immunomodulatory effect.

　　Zinc oxide can also reduce intestinal ion secretion, enhance water absorption and prevent diarrhea. In production, supplementing weaned piglets with relatively high doses of zinc oxide (2500 mg/kg) for a short period can improve the stability and diversity of intestinal flora, and reduce the adhesion of pathogenic bacteria such as enterotoxigenic Escherichia coli (ETEC) to intestinal villi after changes in the diet of weaned piglets.

　　In addition, Zinc oxide it can also prevent the proliferation of opportunistic pathogens such as E. coli and enterococci in the intestine.

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